Phosphoglycerate dehydrogenase

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Human phosphoglycerate dehydrogenase dimer complex with malate and cofactor NAD 2g76

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Function

Phosphoglycerate dehydrogenase (PGDH) catalyzes the conversion of 3-phosphoglycerate into 3-phosphohydroxypyruvate. This is the first step of serine biosynthesis. NAD is used as cofactor. In some cancer cells there is an elevation in PGDH level.

Structural highlights

See Rossmann fold.

3D structures of phosphoglycerate dehydrogenase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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