From Proteopedia
proteopedia linkproteopedia link | FIS protein (Factor for Inversion Stimulation) is a regulatory protein in E. coli that activates ribosomal RNA transcription by binding to RNA promoter and enhances transcription by 5 to 10-fold. FIS binds to a sequence which stimulates hin-mediated DNA inversion and causes DNA bending. FIS affects the bacterial chromosome structure and the initiation of DNA replication. FIS exhibits autoregulation. It is abundant during E. coli exponential growth in rich medium and scarce during the stationary phase[1].
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3D Structures of FIS protein
Updated on 21-February-2016
1fia, 3fis, 4fis, 1ety – EcFIS - Escherichia coli
1f36, 1etk, 1eto, 1etq, 1etv, 1etw, 1etx – EcFIS (mutant)
1fip – EcFIS (mutant) + peptide
3iv5, 3jr9, 3jra, 3jrb, 3jrc 3jrd, 3jre, 3jrf, 3jrg, 3jrh, 3jri, 4ihv, 4ihw, 4ihx, 4ihy – EcFIS + DNA
References
- ↑ Travers A, Schneider R, Muskhelishvili G. DNA supercoiling and transcription in Escherichia coli: The FIS connection. Biochimie. 2001 Feb;83(2):213-7. PMID:11278071
