Sandbox Reserved 426

From Proteopedia

proteopedia linkproteopedia link

This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439.

Contents 1 Structure of Oligonucleotide/Drug complex (1xcs) 2 Introduction 3 Overall Structure 4 Binding Interactions 5 Additional Features 6 Quiz Question 1 7 See Also 8 Credits 9 References

Structure of Oligonucleotide/Drug complex (1xcs)

by Michael Beauregard, Annie Burton, Jianlong Li, Daniel Marco, and Nathaneal Park

Student Projects for UMass Chemistry 423 Spring 2016

Introduction

spinqualitylabelsall models 1xcs, Hello Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Notice the similarity in shape and side chains.

Overall Structure

spinqualitylabelsall models Three dimensional representation of the 1xcs structure. Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

The 1xcs (model at right) protein is a small, simple globular protein lacking any clear secondary beta sheets or alpha helices. The protein consists of two non-identical dimers. A simplified model of 1xcs is shown with the side chains removed for clarity. The protein can be followed from N to C terminus following along each strand from blue to red. Note that the strands are antiparallel where they are non-covalently bound. visualizes this bonding in the middle region of the protein, again following each strand from blue to red from N to C terminus.

Binding Interactions

spinqualitylabelsall models pdbcode, :) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Additional Features

spinqualitylabelsall models pdbcode, akjnfja Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Quiz Question 1

spinqualitylabelsall models 1xcs, chemchemchem Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

A unique site is the __ ion found associated with the , which gives additional strength to the guanine–Co2+–guanine interaction. A Mg2+ B Co2+ C Ba2+ D Mg2+

See Also

• 1bp8
• 1d3x
• 1p3x

Credits

Introduction - Daniel Marco

Overall Structure - Nathaneal Park

Drug Binding Site - name of team member

Additional Features - name of team member

Quiz Question 1 - name of team member

References