The Berndsen Lab is located in the Department of Chemistry and Biochemistry at James Madison University in Harrisonburg, VA. The primary research focus is the mechanism enzymes involved in the conjugation and processing of ubiquitin and ubiquitin-like proteins. Additionally, the lab is interested in integrating protein structure research and molecular basis for disease into the biochemistry classroom.
Research Highlights
Ubiquitin and Ubiquitin-like proteins are linked to many cellular functions included protein degradation and DNA damage repair
[1][2]. The Berndsen Lab is interested in the catalytic mechanisms the conjugating enzymes E1, E2, and E3 use to attach ubiquitin/ubiquitin-like proteins to the substrate lysine. We are also interested in the proteases that remove these modifications and the chemical mechanism(s) of catalysis. We are currently focusing on UFM1
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Disease
Relevance
Structural highlights
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