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Forkhead box protein
From Proteopedia
Contents |
Function
Forkhead box proteins (FOX) are transcription factors involved in regulation of gene expression.[1]. For details on individual FOX proteins, see
See also
Transcription and RNA Processing
Neurodevelopmental Disorders.
Disease
FOX mutations are implicated in congenital heart disease[2].
Structural highlights
FOX contain a DNA-binding motif (DBD) of 80-100 amino acids having a winged-helix shape.
3D structures of FOX
Updated on 02-March-2016
References
- ↑ Tuteja G, Kaestner KH. SnapShot: forkhead transcription factors I. Cell. 2007 Sep 21;130(6):1160. PMID:17889656 doi:http://dx.doi.org/10.1016/j.cell.2007.09.005
- ↑ Zhu H. Forkhead box transcription factors in embryonic heart development and congenital heart disease. Life Sci. 2016 Jan 1;144:194-201. doi: 10.1016/j.lfs.2015.12.001. Epub 2015 Dec, 2. PMID:26656470 doi:http://dx.doi.org/10.1016/j.lfs.2015.12.001
