Gal3-Gal80-Gal4

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spinqualitylabelsall models PDB ID 1d66 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
Yeast Gal4 complex with DNA and Zn+2 ions 1d66
Ligands:
Structural annotation: Resources: CATH : 1D66B01 InterPro : Ipr007219, Ipr005600, Ipr001138, Ipr002409 Pfam : PF00172, PF03902 SCOP : d1d66a2, d1d66a1, d1d66b1, d1d66b2 UniProt : P04386
Functional annotation: Cellular component: nucleus Biological process: carbohydrate metabolic process positive regulation of transcription by galactose transcription galactose metabolic process regulation of transcription, DNA-dependent Molecular function: transcription factor activity DNA binding metal ion binding transcription activator activity zinc ion binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Function

Gal3-Gal80-Gal4 proteins of yeast comprise a signal transducer that controls the galactose-inducible Gal4-mediated transcription activation of GAL regulon genes. Gal3 and Gal4^[1] are regulators of the rapid induction of the galactose system. In the absence of galactose Gal80^[2] binds to Gal4 and prohibits it from activating transcription. In the presence of galactose, Gal3 binds to Gal80 to prohibit its inhibition of Gal4. For Gal4 details see
User:Amir Mitchell/Gal4
User: Wayne Decatur/Gal 4
Evans Gal4
DNA-protein interactions.

The Gal4 protein consists of a of identical subunits.

3D Structures of Gal3-Gal80-Gal4

Updated on 03-March-2016

References

1. ↑ Traven A, Jelicic B, Sopta M. Yeast Gal4: a transcriptional paradigm revisited. EMBO Rep. 2006 May;7(5):496-9. PMID:16670683 doi:http://dx.doi.org/10.1038/sj.embor.7400679
2. ↑ Pilauri V, Bewley M, Diep C, Hopper J. Gal80 dimerization and the yeast GAL gene switch. Genetics. 2005 Apr;169(4):1903-14. Epub 2005 Feb 3. PMID:15695361 doi:http://dx.doi.org/10.1534/genetics.104.036723