Galactosidase

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Contents 1 Function 2 Disease 3 3D Structures of Galactosidase 4 References

Function

α-Galactosidase (Agal) hydrolyzes the terminal α-galactosyl moiety from glycoproteins and glycolipids^[1]. β-Galactosidase (Bgal) hydrolyzes β-galactosides into monosaccharides^[2]. Isopropyl-β-d-thiogalactopyranoside (IPTG) induces Bgal activity. Phenylethyl-β-d-thiogalactopyranoside (PETG) is an inhibitor. Galactose, lactose, o-nitrophenyl-β-d-galactoside (ONPG) are substrates. Galactopyranosyl is reaction intermediate. For details on β-galactosidase see Molecular Playground/Beta-galactosidase.

Disease

The inherited deficiency of Agal is the cause of Fabry disease^[3]. Bgal deficiency can lead to galactosialidosis^[4].

3D Structures of Galactosidase

Updated on 03-March-2016

For 3hg2 .

References

1. ↑ Garman SC, Garboczi DN. The molecular defect leading to Fabry disease: structure of human alpha-galactosidase. J Mol Biol. 2004 Mar 19;337(2):319-35. PMID:15003450 doi:10.1016/j.jmb.2004.01.035
2. ↑ Jacobson RH, Zhang XJ, DuBose RF, Matthews BW. Three-dimensional structure of beta-galactosidase from E. coli. Nature. 1994 Jun 30;369(6483):761-6. PMID:8008071 doi:http://dx.doi.org/10.1038/369761a08015589
3. ↑ Kint JA. Fabry's disease: alpha-galactosidase deficiency. Science. 1970 Feb 27;167(3922):1268-9. PMID:5411915
4. ↑ Weil-Hillman G, Levi R, Zakay-Rones Z. Increase in concanavalin A cap formation on lymphoma cells following interaction with inactive influenza viruses. Acta Virol. 1991 May;35(3):238-46. PMID:1683129

• Created with the participation of Wayne Decatur.