Glutamate synthase

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spinqualitylabelsall models Ferredoxin-dependent glutamate synthase containing a Fe3-S4 cluster complex with FMN, 2-oxo-glutarate (PDB code 1llw) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Glutamate synthase (GS) catalyzes the reverse reaction which converts L-glutamine, 2-oxo-glutarate and NADPH to L-glutarate and NADP. [1]. Fd-dependent glutamate synthase catalyzes the reverse reaction converting L-glutamate and oxidized ferredoxin to L-glutamine, 2-oxo-glutarate and oxidized ferredoxin[2]. Disease Relevance Structural highlights

3D structures of glutamate synthase

Updated on 09-March-2016

References

1. ↑ Vanoni MA, Curti B. Structure-function studies of glutamate synthases: a class of self-regulated iron-sulfur flavoenzymes essential for nitrogen assimilation. IUBMB Life. 2008 May;60(5):287-300. doi: 10.1002/iub.52. PMID:18421771 doi:http://dx.doi.org/10.1002/iub.52
2. ↑ Hirasawa M, Tamura G. Flavin and iron-sulfur containing ferredoxin-linked glutamate synthase from spinach leaves. J Biochem. 1984 Apr;95(4):983-94. PMID:6746604