Gramicidin

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Gramicidin D dimer with formyl-valine, formyl-isoleucine complex with PEG 1500 and ethanolamine , 2xdc

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Function

Gramicidin (GCDN) is a polypeptide composed of alternating L- and D-amino acids. It is produced by the bacteria Bacillus brevis[1].

  • GCDN S is an antibiotic cyclic polypeptide.
  • GCDN D is a mixture of GCDN A, B, C.

See theoretical model of Gramicidin Channel in Lipid Bilayer.

Relevance

GCDN has bactericidal activity and is used as a topical antibiotic and as topical contraceptive[2].

3D Structures of Gramicidin

Updated on 16-March-2016

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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