Histone deacetylase

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Contents 1 Function 2 Relevance 3 3D Structures of histone deacetylase 4 References

Function

Histone deacetylase (HDAC) catalyzes the removal of acetyl group from ε-N-acetyl lysine in histones^[1]. HDAC contains Zn. DNA expression is regulated by acetylation and de-acetylation. HDAC are classified according to their domain organization to 4 classes. SAHA is a common inhibitor of HDAC. For additional details see

• Understanding of the Recruitment of HDACs by MEF2, Based on Their Structure
  
• Transcription and RNA Processing.

Relevance

HDAC inhibitors are used in cancer therapy^[2].

3D Structures of histone deacetylase

Updated on 23-March-2016

References

1. ↑ Joshi P, Greco TM, Guise AJ, Luo Y, Yu F, Nesvizhskii AI, Cristea IM. The functional interactome landscape of the human histone deacetylase family. Mol Syst Biol. 2013;9:672. doi: 10.1038/msb.2013.26. PMID:23752268 doi:http://dx.doi.org/10.1038/msb.2013.26
2. ↑ Marks P, Rifkind RA, Richon VM, Breslow R, Miller T, Kelly WK. Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer. 2001 Dec;1(3):194-202. PMID:11902574 doi:http://dx.doi.org/10.1038/35106079