Intercellular adhesion molecule

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spinqualitylabelsall models Structure of glycosylated human ICAM-1 domains 1-2 (grey and pink) complex with LFA-1 (yellow and green) and Mg+2 ion (green) (PDB code 1mq8). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Intercellular adhesion molecule (ICAM) is part of the immunoglobulin superfamily. ICAM binds to leukocyte function associated molecule 1 (LFA-1) and macrophage-1 antigen during inflammation[1]. ICAM contains 5 Ig-like domains. Disease ICAM mutation is involved in multiple sclerosis[2].

3D structures of intercellular adhesion molecule

Updated on 29-March-2016

References

1. ↑ van de Stolpe A, van der Saag PT. Intercellular adhesion molecule-1. J Mol Med (Berl). 1996 Jan;74(1):13-33. PMID:8834767
2. ↑ Nejentsev S, Laaksonen M, Tienari PJ, Fernandez O, Cordell H, Ruutiainen J, Wikstrom J, Pastinen T, Kuokkanen S, Hillert J, Ilonen J. Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis. Hum Immunol. 2003 Mar;64(3):345-9. PMID:12590979