This is a default text for your page Allie Paton/Sandbox 1181. Click above on http://sbkb.org/fs/glucagon-receptor to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Introduction
Signaling is via coupling to heterotrimeric G-proteins
Activates adenylate cyclase
Upregulates intracellular cAMP
Upregulates inositol phosphate
Increases intracellular Ca2+
Comparisons to other G proteins
Structural similarities
Similarities between Class A and
Sequential similarities
Snake Chain
Functions of Glucagon receptor
Peptide binding and selectivity
from presentation
Conformational changes
Signaling pathway involvement
Textbook Reference
Kinetics
Ligand specifics
Peptide sequence
Active binding domains/sites
Dean can add images
Biological function of glucagon
Signaling pathways
Clinical relevance
Future research direction
Current drug targets
See “Landmark studies on the glucagon subfamily of GPCRs: from small molecule
modulators to a crystal structure” good clinical references and small molecule
target tables
Possible structural considerations for agonists
(our distance measurements and shape analysis images)
Also see Landmark studies on the glucagon subfamily of GPCRs: from small
molecule modulators to a crystal structure
Relevance
Class B in Comparison to Class A
Structural Similarities
Sequential Similarities
Current Drug Targets
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