Ion channels

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Contents 1 Function 2 Classification 3 Additional Resources 4 3D structures of ion channels 5 Weblinks 6 References

Function

Ion channels are membrane proteins that catalyze the passive transport of ions through the cell membrane. Most ion channels are specific to an ion, like the sodium channels, or the potassium channels. Some, like the TRP channels, let through various cations. Another property of ion channels is that they can be either driven by voltage or by concentration gradients, or they can be gated (by voltage, ligands, touch and other sensory signal). Potassium channels (KCh) are subdivided to voltage-gated KCh and calcium-dependent KCh. The latter are subdivided into high- (BK, LKCa), intermediate- and small-conductance KCh (human SK1, rat SK2, SKCa). MthK is a calcium-dependent potassium channel from Methanobacterium thermoautrophicum. MscL and MscS are large- and small-conductance mechanosensitive channels which protect bacteria from osmotic shock by allowing ions to flow across the cell membrane Mechanosensitive channels: opening and closing. Voltage-Dependent Calcium Channels (VDCC) allow Ca+2 ions to enter the cell resulting in muscle contraction, neuron excitation or hormone release. VDCC are composed of several subunits and are named as a Cav gene product. The human annexin V molecule serves as a calcium channel. There are also Voltage-Dependent Anion Channels (VDAC). Chloride ion channels (ClCh) are involved in maintaining pH, volume homeostasis and more. Ligand-Gated Ion Channels (LGIC) open or close when binding a ligand like a neurotransmitter. The Cyclic Nucleotide-Gated channels (CNGC) conduct cations upon binding of cAMP or cGMP. The Acid-Sensitive channels (ASC) conduct cations upon binding of acid. The glycerol facilitator (GlpF) is a protein channel which transports glycerol across the cell membrane of E. coli. Other ion channel proteins are the aquaporins, gramicidin, antiamoebin, trichotoxin, peptaibol and the glutamate receptor. Finally, ion channels are the fastest of all membrane transporters, with 10⁶ to 10⁸ transported units per second versus 10² to 10⁴ molecules per second for porters/carriers, or 10⁰ to 10³ for ATP-driven pumps. Specific details in:

• Proton Channels,
  
• Membrane Channels & Pumps,
  
• M2 Proton Channel,
  
• M2 Proton Channel Inhibitor Pharmacokinetics,
  
• User:Michael Strong/H1N1/MP give details on proton channels,
  
• User:Michael Strong/H1N1/MP1/MSA,
  
• User:Michael Strong/H1N1/MP2/MSA for multiple sequence alignment
  
• Chloride Ion Channel
  
• User:Laura Fountain/Chloride Ion Channel
  
• Chloride Intracellular Channel Protein 2
  
• Mechanosensitive channels: opening and closing
  
• Voltage-gated calcium channels
  
• Ryanodine receptor.
  
• Hypertension & Congestive Heart Failure.

Classification

TCDB, the most sophisticated classification of transport proteins to date, classify ion channels as a heterogenous subset of all α-type channels, whose singular property is to consist mainly of α-helices that span the membrane. They are distinct in this from the beta-barrel porins and the pore-forming toxins, as well as from non-ribosomally synthesized channels like gramicidin, polyglutamine or digitoxin. All these proteins are passive transport proteins.

Additional Resources

For additional information, see: Membrane Channels & Pumps
For additional information, see: Hypertension & Congestive Heart Failure

3D structures of ion channels

Updated on 30-March-2016

Weblinks

• The TCDB database
• TCDB: 1.A α-Type channels
• TCDB: Transport proteins with PDB structures

References