XPD Helicase (3CRV)

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Contents 1 XPD Helicase 2 Function 3 Disease 4 Relevance 5 Structural highlights 6 References

XPD Helicase

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Function

-Required for nucleotide excision repair (NER) as part as transcription factor/repair complex TFIIH -Critical for helicase activity and stability and the TFIIH complex -DNA helicase is essential during DNA replication because it unwinds the two strands at places called origins, where synthesis is initiated. This allows both strands of DNA to be replicated. XPD helicase activity is essential for NER but dispensable for transcription -NER removes DNA damaged by ultraviolet light

Disease

Xeroderma Pigmentosum(XP)

Cockayne Syndrome combined with XP (XP/CS)

Trichothiodystrophy(TTD)

Relevance

Structural highlights

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References

Fan, L., Fuss, J. O., Cheng, Q. J., Arvai, A. S., Hammel, M., Roberts, V. A., Cooper, P. K., and Tainer, J. A. (2008) XPD helicase structures and activities: Insights into the cancer and aging phenotypes from XPD mutations.