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Methanol dehydrogenase
From Proteopedia
Contents |
Function
Methanol dehydrogenase (MDH) is a quinoprotein which catalyzes the conversion of methanol and NAD+ or NADP+ to formaldeyde and NADH or NADPH and H+. MDH is a pyrroloquinoline quinone (PQQ)-dependent enzyme. MDH requires a divalent cation like Ca+2 for catalytic activity[1].
Structural highlights
PQQ and Ca+2 are bound in a funnel-shaped internal cavity of MDH[2].
3D structures of methanol dehydrogenase
Updated on 21-April-2016
4aah, 1g72, 2ad6, 2ad7, 2ad8 – MmMDH α+β + Ca + PQQ – Methylophilus methylotrophus
1h4i, 1w6s - MeMDH α+β + Ca + PQQ – Methylobacterium extorquens
1h4j - MeMDH α (mutant) +β + Ca + PQQ
1lrw - MDH α+β + Ca + PQQ – Paracoccus denitrificans
2d0v - MDH α+β + Ca + PQQ – Hyphomicrobium denitrificans
4mae - MDH + Ce + PQQ – Methylacidiphilum fumariolicum
4tqo - MDH + Ca + PQQ – Methylococcus capsulatus
References
- ↑ Anthony C, Williams P. The structure and mechanism of methanol dehydrogenase. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):18-23. PMID:12686102
- ↑ Li J, Gan JH, Mathews FS, Xia ZX. The enzymatic reaction-induced configuration change of the prosthetic group PQQ of methanol dehydrogenase. Biochem Biophys Res Commun. 2011 Mar 25;406(4):621-6. Epub 2011 Feb 26. PMID:21356200 doi:10.1016/j.bbrc.2011.02.107
