Methylcitrate synthase

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Template:STRUCTURE 3tqg

Methylcitrate synthase (MCS) participates in propanoate metabolism. It catalyzes the conversion of acyl to alkyl group in the reaction which converts propanoyl-CoA and oxaloacetate to 2-hydroxybutane-1,2,3-tricarboxylate and CoA[1].

See also Citrate Synthase.

3D structures of methylcitrate synthase

3hwk – MCS – Mycobacterium tuberculosis
3o8j – MCS – Salmonella enterica
3tqg – MCS – Coxiella burnetii

References

  1. ↑ Horswill AR, Escalante-Semerena JC. Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle. J Bacteriol. 1999 Sep;181(18):5615-23. PMID:10482501

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Michal Harel, Alexander Berchansky

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