Myosin light chain kinase

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Template:STRUCTURE 2x4f


Myosin light chain kinase (MLCK) phosphorylates the regulatory light chain of myosin at serine residue 19. This phosphorylation enables the myosin crossbridge to bind to the actin filament and allows muscle contraction to begin. Dephosphorylation of the myosin light chain stops muscle contraction[1].

3D structures of MLCK

2cqv – hMLCK 8th Ig-like domain – human – NMR
2yr3 - hMLCK 4th Ig-like domain – NMR
2x4f – hMLCK residues 40-388

References

  1. ↑ Stull JT, Tansey MG, Tang DC, Word RA, Kamm KE. Phosphorylation of myosin light chain kinase: a cellular mechanism for Ca2+ desensitization. Mol Cell Biochem. 1993 Nov;127-128:229-37. PMID:7935354

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Michal Harel, Alexander Berchansky

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