NAD(P) transhydrogenase

NAD(P) transhydrogenase (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. See NAD and NAD(P)H. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change^[1]. PTH uses FAD as cofactor.

Structural highlights

PTH is composed of 3 domains:

• Domain I binds NAD(+)/NADH.
  
• Domain II is a membrane-spanning domain.
  
• Domain III binds NADP(+)/NADPH.
  

PTH is composed of 2 subunits. Subunit beta contains domain III and part of II.