This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Neuraminidase
From Proteopedia
Contents |
Function
Neuraminidase (NAN) cleaves the glycosidic bonds of neuraminic acid[1].
- endo-neuraminidase is a phage neuraminidase which cleaves α-2,8-polysialic acid[2].
- Pseudaminidase is a Pseudomonas aeruginosa neuraminidase.
- Trans-sialidase transfers sialic acid from Trypanosoma cruzi to a host cell[3].
See also
- Avian Influenza Neuraminidase, Tamiflu and Relenza
- Zanamivir (Relenza)
- Molecular Playground/Relenza
- Molecular Playground/Tamiflu
- Oseltamivir (Tamiflu)
- Treatments:Influenza
- User:Michael Strong/H1N1/NA for Influenza virus neuraminidase
- User:Michael Strong/H1N1/NA/MSA for multiple sequence alignment.
For other inhibitors see
- Neuraminidase Inhibitor Pharmacokinetics
- Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose
- Treatments:Neuraminidase Inhibitor Pharmacokinetics References
.
Relevance
The viral NAN is a drug target for prevention of influenza[4]. In Chagas disease trans-sialidase on the surface of Trypanosoma cruzi participate in host-parasite interactions and mediate the initial stages of the invasion of the host cell[5].
3D structures of Neuraminidase
Updated on 08-May-2016
References
- ↑ Matrosovich MN, Matrosovich TY, Gray T, Roberts NA, Klenk HD. Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium. J Virol. 2004 Nov;78(22):12665-7. PMID:15507653 doi:http://dx.doi.org/10.1128/JVI.78.22.12665-12667.2004
- ↑ Rutishauser U, Watanabe M, Silver J, Troy FA, Vimr ER. Specific alteration of NCAM-mediated cell adhesion by an endoneuraminidase. J Cell Biol. 1985 Nov;101(5 Pt 1):1842-9. PMID:4055897
- ↑ Colli W. Trans-sialidase: a unique enzyme activity discovered in the protozoan Trypanosoma cruzi. FASEB J. 1993 Oct;7(13):1257-64. PMID:8405811
- ↑ Sylte MJ, Suarez DL. Influenza neuraminidase as a vaccine antigen. Curr Top Microbiol Immunol. 2009;333:227-41. doi: 10.1007/978-3-540-92165-3_12. PMID:19768409 doi:http://dx.doi.org/10.1007/978-3-540-92165-3_12
- ↑ Schenkman S, Eichinger D, Pereira ME, Nussenzweig V. Structural and functional properties of Trypanosoma trans-sialidase. Annu Rev Microbiol. 1994;48:499-523. PMID:7826016 doi:http://dx.doi.org/10.1146/annurev.mi.48.100194.002435
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Eran Hodis
