Neutrophil gelatinase-associated lipocalin

From Proteopedia

proteopedia linkproteopedia link

spinqualitylabelsall models Structure of human neutrophil gelatinase-associated lipocalin complex with Fe+3 ion and carboxymycobactin (PDB code 1x71). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Neutrophil gelatinase-associated lipocalin (NGAL) or lipocalin-2 is involved in innate immunity by sequestering bacterial iron and thus preventing bacterial growth[1]. Disease Relevance NGAL is secreted in high levels into the blood following acute kidney injury and thus can be used as a biomarker for it[2]. Structural highlights

3D structures of neutrophil gelatinase-associated lipocalin

Updated on 10-May-2016

References

1. ↑ Friedl A, Stoesz SP, Buckley P, Gould MN. Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression. Histochem J. 1999 Jul;31(7):433-41. PMID:10475571
2. ↑ Viau A, El Karoui K, Laouari D, Burtin M, Nguyen C, Mori K, Pillebout E, Berger T, Mak TW, Knebelmann B, Friedlander G, Barasch J, Terzi F. Lipocalin 2 is essential for chronic kidney disease progression in mice and humans. J Clin Invest. 2010 Nov;120(11):4065-76. doi: 10.1172/JCI42004. PMID:20921623 doi:http://dx.doi.org/10.1172/JCI42004