4zwn

Structural highlights

Function

[MGLL_YEAST] Converts monoacylglycerides (MAG) to free fatty acids and glycerol. Required for efficient degradation of MAG, short-lived intermediates of glycerolipid metabolism which may also function as lipid signaling molecules. Controls inactivation of the signaling lipid N-palmitoylethanolamine (PEA).^{[1] [2]}

References

1. ↑ Muccioli GG, Sia A, Muchowski PJ, Stella N. Genetic manipulation of palmitoylethanolamide production and inactivation in Saccharomyces cerevisiae. PLoS One. 2009 Jun 16;4(6):e5942. doi: 10.1371/journal.pone.0005942. PMID:19529773 doi:http://dx.doi.org/10.1371/journal.pone.0005942
2. ↑ Heier C, Taschler U, Rengachari S, Oberer M, Wolinski H, Natter K, Kohlwein SD, Leber R, Zimmermann R. Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomycescerevisiae. Biochim Biophys Acta. 2010 Sep;1801(9):1063-71. doi:, 10.1016/j.bbalip.2010.06.001. Epub 2010 Jun 8. PMID:20554061 doi:http://dx.doi.org/10.1016/j.bbalip.2010.06.001