Nuclear receptor coactivator

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Template:STRUCTURE 1oj5

Nuclear receptor coactivator (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors[1].

  • NCOA1 shows histone acetyltransferase activity and is required for steroid hormone response.
  • NCOA2 is a DNA transcription coactivator with glucocorticoid receptor.
  • NCOA3 shows histone acetyltransferase activity.
  • NCOA5 is both a DNA transcription coactivator and corepressor. It interacts with steroid receptor.

3D structures of nuclear receptor coactivator

1v95 – hNCOA5 – human - NMR
1kbh – hNCOA + CREB-binding protein - NMR
2c52 – hNCOA1 residues 920-970 + CREB-binding protein - NMR
1oj5 – NCOA1A Pas-B domain + signal transducer and activator of transcription peptide - mouse

References

  1. ↑ Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L. Nuclear receptor coactivators and corepressors. Mol Endocrinol. 1996 Oct;10(10):1167-77. PMID:9121485 doi:http://dx.doi.org/10.1210/mend.10.10.9121485

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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