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1ivo
From Proteopedia
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| , resolution 3.30Å | |||||||
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| Ligands: | |||||||
| Activity: | Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 | ||||||
| Related: | 1JL9
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.
Overview
Epidermal growth factor (EGF) regulates cell proliferation and differentiation by binding to the EGF receptor (EGFR) extracellular region, comprising domains I-IV, with the resultant dimerization of the receptor tyrosine kinase. In this study, the crystal structure of a 2:2 complex of human EGF and the EGFR extracellular region has been determined at 3.3 A resolution. EGFR domains I-III are arranged in a C shape, and EGF is docked between domains I and III. The 1:1 EGF*EGFR complex dimerizes through a direct receptor*receptor interaction, in which a protruding beta-hairpin arm of each domain II holds the body of the other. The unique "receptor-mediated dimerization" was verified by EGFR mutagenesis.
About this Structure
1IVO is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains., Ogiso H, Ishitani R, Nureki O, Fukai S, Yamanaka M, Kim JH, Saito K, Sakamoto A, Inoue M, Shirouzu M, Yokoyama S, Cell. 2002 Sep 20;110(6):775-87. PMID:12297050
Page seeded by OCA on Sun Mar 30 21:25:17 2008
Categories: Homo sapiens | Protein complex | Transferase | Fukai, S. | Ishitani, R. | Kim, J H. | Nureki, O. | Ogiso, H. | RSGI, RIKEN Structural Genomics/Proteomics Initiative. | Saito, K. | Shirouzu, M. | Yamanaka, M. | Yokoyama, S. | Glycoprotein | Receptor | Repeat | Riken structural genomics/proteomics initiative | Rsgi | Signal, | Structural genomic | Transmembrane
