5cy0

Structural highlights

Function

[SCX3_TITSE] Binds voltage-dependently at site-3 of sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals (mice).^{[1] [2] [3]}

References

1. ↑ Campos FV, Moreira TH, Beirao PS, Cruz JS. Veratridine modifies the TTX-resistant Na+ channels in rat vagal afferent neurons. Toxicon. 2004 Mar 15;43(4):401-6. PMID:15051403 doi:http://dx.doi.org/10.1016/j.toxicon.2004.01.012
2. ↑ Campos FV, Coronas FI, Beirao PS. Voltage-dependent displacement of the scorpion toxin Ts3 from sodium channels and its implication on the control of inactivation. Br J Pharmacol. 2004 Aug;142(7):1115-22. Epub 2004 Jul 12. PMID:15249424 doi:http://dx.doi.org/10.1038/sj.bjp.0705793
3. ↑ Kirsch GE, Skattebol A, Possani LD, Brown AM. Modification of Na channel gating by an alpha scorpion toxin from Tityus serrulatus. J Gen Physiol. 1989 Jan;93(1):67-83. PMID:2536799