Parvalbumin

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spinqualitylabelsall models Pike parvalbumin complex with Ca+2 ions (green), ammonium, acetyl and formate (PDB entry 2pvb) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Parvalbumin (PVA) is a calcium-binding albumin protein. PVA is involved in calcium signaling[1]. PVA contains 3 domains: AB, CD (N-terminal) and EF (C-terminal). See also EF hand Parvalbumin carp. Structural highlights PVA contains a heptacoordinated Ca+2 ion binding to 7 oxygen atoms in a typical EF-hand coordination[2].

3D Structures of Parvalbumin

Updated on 15-June-2016

References

1. ↑ Cates MS, Teodoro ML, Phillips GN Jr. Molecular mechanisms of calcium and magnesium binding to parvalbumin. Biophys J. 2002 Mar;82(3):1133-46. PMID:11867433 doi:http://dx.doi.org/10.1016/S0006-3495(02)75472-6
2. ↑ Declercq JP, Evrard C, Lamzin V, Parello J. Crystal structure of the EF-hand parvalbumin at atomic resolution (0.91 A) and at low temperature (100 K). Evidence for conformational multistates within the hydrophobic core. Protein Sci. 1999 Oct;8(10):2194-204. PMID:10548066