Peroxiredoxin

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Template:STRUCTURE 1qq2

Contents 1 Function 2 Relevance 3 3D Structures of Peroxiredoxin 4 References

Function

Peroxiredoxin (Prx) is an antioxidant enzyme. In the Prxs the active-site Cys is oxidized to sulfenic acid byperoxide. The Prxs are divided into typical 2-Cys Prx, atypical 2-Cys Prx and 1-Cys Prx. Prx 5 is expressed in mammalian tissue.

Relevance

Prx are over expressed in cancer tissue^[1].

3D Structures of Peroxiredoxin

Updated on 21-June-2016

References

1. ↑ Noh DY, Ahn SJ, Lee RA, Kim SW, Park IA, Chae HZ. Overexpression of peroxiredoxin in human breast cancer. Anticancer Res. 2001 May-Jun;21(3B):2085-90. PMID:11497302