Phosphoserine aminotransferase

Function

Phosphoserine aminotransferase (PSAT) catalyzes the reversible conversion of phosphoserine and oxoglutarate to produce glutamate and 3-phosphonooxypyruvate. PSAT is part of the phosphoserine biosynthesis^[1]. Pyridoxal phosphate (vitamin B6, PLP) is a cofactor of PAT.

Relevance

PSAT is over-expressed in colon tumors and its inhibition is being tested as drug treatment.

3D structures of phosphoserine aminotransferase

Updated on 30-June-2016

References

1. ↑ Basurko MJ, Marche M, Darriet M, Cassaigne A. Phosphoserine aminotransferase, the second step-catalyzing enzyme for serine biosynthesis. IUBMB Life. 1999 Nov;48(5):525-9. PMID:10637769 doi:http://dx.doi.org/10.1080/713803557