Function
Phycocyanobilin:ferredoxin oxidoreductase (PcyA) is a member of the Fd-dependent bilin family. PcyA reduces vinyl groups of biliverdin IX-α to yield phycocyanobilin[1]. Phycocyanobilin is a pigment precursor of the light-harvesting antennae in red algae and cyanobacteria.
3D Structures of Phycocyanobilin:ferredoxin oxidoreductase
3ajg, 3i95 – SyPcyA (mutant) + biliverdin IX – Synechocystis
3ajh – SyPcyA (mutant) + biliverdin XIII
3i94 - SyPcyA + biliverdin XIII
3f0l, 3fom, 3nb8, 3nb9 – SyPcyA (mutant)
3i8u – SyPcyA + biliverdin derivative
References
- ↑ Tu SL, Gunn A, Toney MD, Britt RD, Lagarias JC. Biliverdin reduction by cyanobacterial phycocyanobilin:ferredoxin oxidoreductase (PcyA) proceeds via linear tetrapyrrole radical intermediates. J Am Chem Soc. 2004 Jul 21;126(28):8682-93. PMID:15250720 doi:http://dx.doi.org/10.1021/ja049280z
