Plasminogen activator

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Plasminogen activator (PLA) is a serine protease which converts plasminogen to plasmin. TPA structure contains heavy and light chains (HC, LC). PLA is inhibited by PLA inhibitor 1 and 2.

  • Tissue PLA (TPA) which is involved in breakdown of blood clots and urokinase-type PLA Urokinase.

Relevance

Treatment with tissue PLA for acute ischemic stroke is beneficial[1].

3D structures of plasminogen activator

Updated on 04-July-2016


References

  1. ↑ . Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995 Dec 14;333(24):1581-7. PMID:7477192 doi:http://dx.doi.org/10.1056/NEJM199512143332401

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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