Plasminogen activator inhibitor

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Plasminogen activator inhibitor (PAI) is a serine protease inhibitor.

  • PAI-1 inhibits tissue plasminogen activator and urokinase[1].
  • PAI-2 is secreted by the placenta and is present during pregnancy[2].
  • PAI-3 or protein C inhibitor inhibits enzymes in blood coagulation[3].

3D Structures of plasminogen activator inhibitor

Updated on 05-July-2016

References

  1. ↑ Lijnen HR. Pleiotropic functions of plasminogen activator inhibitor-1. J Thromb Haemost. 2005 Jan;3(1):35-45. PMID:15634264 doi:http://dx.doi.org/10.1111/j.1538-7836.2004.00827.x
  2. ↑ Lobov S, Croucher DR, Saunders DN, Ranson M. Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro: potential receptor interactions. Thromb Haemost. 2008 Aug;100(2):319-29. PMID:18690354
  3. ↑ Meijers JC, Marquart JA, Bertina RM, Bouma BN, Rosendaal FR. Protein C inhibitor (plasminogen activator inhibitor-3) and the risk of venous thrombosis. Br J Haematol. 2002 Aug;118(2):604-9. PMID:12139754

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