Proliferating Cell Nuclear Antigen

Function

Proliferating Cell Nuclear Antigen (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells^[1].

Relevance

PCNA is useful in the diagnosis of high-grade dysplasia^[2].

3D Structures of Proliferating Cell Nuclear Antigen

Updated on 12-July-2016

References

1. ↑ Maga G, Hubscher U. Proliferating cell nuclear antigen (PCNA): a dancer with many partners. J Cell Sci. 2003 Aug 1;116(Pt 15):3051-60. PMID:12829735 doi:http://dx.doi.org/10.1242/jcs.00653
2. ↑ Kullmann F, Fadaie M, Gross V, Knuchel R, Bocker T, Steinbach P, Scholmerich J, Ruschoff J. Expression of proliferating cell nuclear antigen (PCNA) and Ki-67 in dysplasia in inflammatory bowel disease. Eur J Gastroenterol Hepatol. 1996 Apr;8(4):371-9. PMID:8781908