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1k09

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Revision as of 18:41, 30 March 2008 by OCA (Talk | contribs)

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Image:1k09.jpg

Ligands:

, , , ,

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein

Overview

BetaCore is a designed approximately 50-residue protein in which two BPTI-derived core modules, CM I and CM II, are connected by a 22-atom cross-link. At low temperature and pH 3, homo- and heteronuclear NMR data report a dominant folded ('f') conformation with well-dispersed chemical shifts, i, i+1 periodicity, numerous long-range NOEs, and slowed amide hydrogen isotope exchange patterns that is a four-stranded antiparallel beta-sheet with nonsymmetrical and specific association of CM I and CM II. BetaCore 'f' conformations undergo reversible, global, moderately cooperative, non-two-state thermal transitions to an equilibrium ensemble of unfolded 'u' conformations. There is a significant energy barrier between 'f' and 'u' conformations. This is the first designed four-stranded antiparallel beta-sheet that folds in water.

About this Structure

1K09 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

BetaCore, a designed water soluble four-stranded antiparallel beta-sheet protein., Carulla N, Woodward C, Barany G, Protein Sci. 2002 Jun;11(6):1539-51. PMID:12021452

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