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Pyruvate dehydrogenase kinase
From Proteopedia
Function
Pyruvate dehydrogenase kinase (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites[1].
Relevance
Inhibition of PDK decreases the damage caused by heart ischemia and are used in diabetes and cancer patients[2][3].
3D structures of pyruvate dehydrogenase kinase
Updated on 02-August-2016
