Ras GTPase activating protein

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Template:STRUCTURE 2j05

Contents 1 Function 2 Relevance 3 3D Structures of Ras GTPase activating protein 4 References

Function

Ras GTPase activating protein (RasGAP) inactivates Ras from its active GTP-bound form to its GDP-bound form^[1]. It is part of the mitogenic signal transmission via its N-terminal SH2-SH3-SH2 domains.

Relevance

Inactivated RasGAP activate RAS which is mutated in 30% of cancer types^[2]. RasGAP Colra1 is involved in infection-related morphogenesis in gourd family plants^[3].

3D Structures of Ras GTPase activating protein

Updated on 03-August-2016

2gqi, 2m51 – hRasGAP SH3 domain – human – NMR
2j05, 2j06, 4fss - hRasGAP SH3 domain
2gsb - hRasGAP SH2 domain – NMR
3bxj - hRasGAP SYNGAP fragment - rat

References

1. ↑ Tocque B, Delumeau I, Parker F, Maurier F, Multon MC, Schweighoffer F. Ras-GTPase activating protein (GAP): a putative effector for Ras. Cell Signal. 1997 Feb;9(2):153-8. PMID:9113414
2. ↑ Maertens O, Cichowski K. An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer. Adv Biol Regul. 2014 May;55:1-14. doi: 10.1016/j.jbior.2014.04.002. Epub 2014 Apr, 30. PMID:24814062 doi:http://dx.doi.org/10.1016/j.jbior.2014.04.002
3. ↑ Harata K, Kubo Y. Ras GTPase activating protein CoIra1 is involved in infection-related morphogenesis by regulating cAMP and MAPK signaling pathways through CoRas2 in Colletotrichum orbiculare. PLoS One. 2014 Oct 2;9(9):e109045. doi: 10.1371/journal.pone.0109045. eCollection, 2014. PMID:25275394 doi:http://dx.doi.org/10.1371/journal.pone.0109045