Structural highlights
4kq6 is a 10 chain structure with sequence from Canga. This structure supersedes the now removed PDB entry 4gef. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , |
| Gene: | CAGL0B01419g, RIB4 (CANGA) |
| Activity: | 6,7-dimethyl-8-ribityllumazine synthase, with EC number 2.5.1.78 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Publication Abstract from PubMed
Candida glabrata has emerged as an important fungal pathogen with intrinsic resistance to azole drugs. The limited efficacy of and resistance to existing antifungals is driving the need to identify new drug targets. The enzyme 6,7-dimethyl-8-(D-ribityl)lumazine synthase is part of the riboflavin-biosynthesis pathway essential to fungi and bacteria and is a potential drug target for the development of broad-spectrum antifungal drugs. The X-ray crystal structure of recombinant lumazine synthase from C. glabrata was obtained at 2.24 A resolution and revealed a dimer of homopentamers, with one in five subunits containing a product molecule from the catalytic reaction.
Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata.,Shankar M, Wilbanks SM, Nakatani Y, Monk BC, Tyndall JD Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1580-6. doi:, 10.1107/S0907444913010949. Epub 2013 Jul 20. PMID:23897480[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Shankar M, Wilbanks SM, Nakatani Y, Monk BC, Tyndall JD. Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata. Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1580-6. doi:, 10.1107/S0907444913010949. Epub 2013 Jul 20. PMID:23897480 doi:10.1107/S0907444913010949
