Structural highlights
Function
[MTERF_HUMAN] Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Probably requires one or more components for termination activity.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The regulation of mitochondrial DNA (mtDNA) processes is slowly being characterized at a structural level. We present here crystal structures of human mitochondrial regulator mTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(Leu)(UUR) gene sequence. mTERF comprises nine left-handed helical tandem repeats that form a left-handed superhelix, the Zurdo domain.
Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat.,Jimenez-Menendez N, Fernandez-Millan P, Rubio-Cosials A, Arnan C, Montoya J, Jacobs HT, Bernado P, Coll M, Uson I, Sola M Nat Struct Mol Biol. 2010 Jul;17(7):891-3. Epub 2010 Jun 13. PMID:20543826[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Yakubovskaya E, Mejia E, Byrnes J, Hambardjieva E, Garcia-Diaz M. Helix unwinding and base flipping enable human MTERF1 to terminate mitochondrial transcription. Cell. 2010 Jun 11;141(6):982-93. PMID:20550934 doi:10.1016/j.cell.2010.05.018
- ↑ Jimenez-Menendez N, Fernandez-Millan P, Rubio-Cosials A, Arnan C, Montoya J, Jacobs HT, Bernado P, Coll M, Uson I, Sola M. Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat. Nat Struct Mol Biol. 2010 Jul;17(7):891-3. Epub 2010 Jun 13. PMID:20543826 doi:10.1038/nsmb.1859
