1ah1

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1ah1

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CTLA-4, NMR, 20 STRUCTURES

Overview

The structure of human CTLA-4 reveals that residues Met 99, Tyr 100 and, Tyr 104 of the M99YPPPY104 motif are adjacent to a patch of charged, surface residues on the A'GFCC' face of the protein. Mutation of these, residues, which are conserved in the CTLA-4/CD28 family, significantly, reduces binding to CD80 and/or CD86, implicating this patch as a ligand, binding site.

About this Structure

1AH1 is a Single protein structure of sequence from Homo sapiens. Structure known Active Sites: GL1 and GL2. Full crystallographic information is available from OCA.

Reference

Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28., Metzler WJ, Bajorath J, Fenderson W, Shaw SY, Constantine KL, Naemura J, Leytze G, Peach RJ, Lavoie TB, Mueller L, Linsley PS, Nat Struct Biol. 1997 Jul;4(7):527-31. PMID:9228944

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