| Structural highlights
Function
[SAS6_DANRE] Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells.[1]
Publication Abstract from PubMed
Centrioles are cylindrical, nine-fold symmetrical structures with peripheral triplet microtubules strictly required to template cilia and flagella. The highly conserved protein SAS-6 constitutes the center of the cartwheel assembly that scaffolds centrioles early in their biogenesis. We determined the x-ray structure of the N-terminal domain of SAS-6 from zebrafish and show that recombinant SAS-6 self-associates in vitro into assemblies that resemble cartwheel centers. Point mutations are consistent with the notion that centriole formation in vivo depends on the interactions that define the self-assemblies observed here. Thus, these interactions are likely essential to the structural organization of cartwheel centers.
Structures of SAS-6 Suggest Its Organization in Centrioles.,van Breugel M, Hirono M, Andreeva A, Yanagisawa HA, Yamaguchi S, Nakazawa Y, Morgner N, Petrovich M, Ebong IO, Robinson CV, Johnson CM, Veprintsev D, Zuber B Science. 2011 Jan 27. PMID:21273447[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ van Breugel M, Hirono M, Andreeva A, Yanagisawa HA, Yamaguchi S, Nakazawa Y, Morgner N, Petrovich M, Ebong IO, Robinson CV, Johnson CM, Veprintsev D, Zuber B. Structures of SAS-6 Suggest Its Organization in Centrioles. Science. 2011 Jan 27. PMID:21273447 doi:10.1126/science.1199325
- ↑ van Breugel M, Hirono M, Andreeva A, Yanagisawa HA, Yamaguchi S, Nakazawa Y, Morgner N, Petrovich M, Ebong IO, Robinson CV, Johnson CM, Veprintsev D, Zuber B. Structures of SAS-6 Suggest Its Organization in Centrioles. Science. 2011 Jan 27. PMID:21273447 doi:10.1126/science.1199325
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