Structural highlights
4l73 is a 2 chain structure with sequence from Metth. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , |
| Related: | 4l74, 4l75, 4l76 |
| Gene: | mthK, MTH_1520 (METTH) |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[MTHK_METTH] Calcium-gated potassium channel.
Publication Abstract from PubMed
Ligand binding sites within proteins can interact by allosteric mechanisms to modulate binding affinities and control protein function. Here we present crystal structures of the regulator of K(+) conductance (RCK) domain from a K(+) channel, MthK, which reveal the structural basis of allosteric coupling between two Ca(2+) regulatory sites within the domain. Comparison of RCK domain crystal structures in a range of conformations and with different numbers of regulatory Ca(2+) ions bound, combined with complementary electrophysiological analysis of channel gating, suggests chemical interactions that are important for modulation of ligand binding and subsequent channel opening.
Structural basis of allosteric interactions among Ca(2+)-binding sites in a K(+) channel RCK domain.,Smith FJ, Pau VP, Cingolani G, Rothberg BS Nat Commun. 2013;4:2621. doi: 10.1038/ncomms3621. PMID:24126388[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Smith FJ, Pau VP, Cingolani G, Rothberg BS. Structural basis of allosteric interactions among Ca(2+)-binding sites in a K(+) channel RCK domain. Nat Commun. 2013;4:2621. doi: 10.1038/ncomms3621. PMID:24126388 doi:http://dx.doi.org/10.1038/ncomms3621
