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1loz
From Proteopedia
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| , resolution 1.8Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | MUTANT HUMAN LYSOZYME (Homo sapiens) | ||||||
| Activity: | Lysozyme, with EC number 3.2.1.17 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
AMYLOIDOGENIC VARIANT (I56T) VARIANT OF HUMAN LYSOZYME
Overview
Tissue deposition of soluble proteins as amyloid fibrils underlies a range of fatal diseases. The two naturally occurring human lysozyme variants are both amyloidogenic, and are shown here to be unstable. They aggregate to form amyloid fibrils with transformation of the mainly helical native fold, observed in crystal structures, to the amyloid fibril cross-beta fold. Biophysical studies suggest that partly folded intermediates are involved in fibrillogenesis, and this may be relevant to amyloidosis generally.
About this Structure
1LOZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis., Booth DR, Sunde M, Bellotti V, Robinson CV, Hutchinson WL, Fraser PE, Hawkins PN, Dobson CM, Radford SE, Blake CC, Pepys MB, Nature. 1997 Feb 27;385(6619):787-93. PMID:9039909
Page seeded by OCA on Sun Mar 30 22:05:32 2008
