1mmj
From Proteopedia
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| , resolution 2.2Å | |||||||
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| Ligands: | , , | ||||||
| Activity: | Pancreatic elastase, with EC number 3.4.21.36 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706
Overview
The crystal structure of porcine pancreatic elastase (PPE) complexed with a potent peptidyl inhibitor, FR136706, was solved at 2.2A resolution. FR136706 fits snugly into the extended active site pocket. The benzene moiety of FR136706 induced dramatic movement of the side chain moiety of Arg217 and both moieties formed a pi-pi interaction, which has never been found previously in structures of PPE complexed with inhibitors. This novel interaction mode may lead to design of new types of inhibitors.
About this Structure
1MMJ is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.
Reference
True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor., Kinoshita T, Nakanishi I, Sato A, Tada T, Bioorg Med Chem Lett. 2003 Jan 6;13(1):21-4. PMID:12467609
Page seeded by OCA on Sun Mar 30 22:18:09 2008
