Structural highlights
Function
[CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
A number of molecular recognition features have been exploited in structure-based design of selective Cathepsin inhibitors.
Design of selective Cathepsin inhibitors.,Bethel PA, Gerhardt S, Jones EV, Kenny PW, Karoutchi GI, Morley AD, Oldham K, Rankine N, Augustin M, Krapp S, Simader H, Steinbacher S Bioorg Med Chem Lett. 2009 Aug 15;19(16):4622-5. Epub 2009 Jun 27. PMID:19616430[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Bethel PA, Gerhardt S, Jones EV, Kenny PW, Karoutchi GI, Morley AD, Oldham K, Rankine N, Augustin M, Krapp S, Simader H, Steinbacher S. Design of selective Cathepsin inhibitors. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4622-5. Epub 2009 Jun 27. PMID:19616430 doi:10.1016/j.bmcl.2009.06.090
