| Structural highlights
4ds7 is a 8 chain structure with sequence from Baker's yeast and Candida sphaerica. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | , , |
| Related: | 1lkj |
| Gene: | CMD1, KLLA0B09427g (Candida sphaerica), SPC110, NUF1, XCM1, YDR356W, D9476.3 (Baker's yeast) |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[CALM_KLULA] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. [SP110_YEAST] Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Potential role in cross-linking filaments or anchoring other molecules. It is essential for growth.[1] [2] [3] [4] [5] [6]
See Also
References
- ↑ Elliott S, Knop M, Schlenstedt G, Schiebel E. Spc29p is a component of the Spc110p subcomplex and is essential for spindle pole body duplication. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6205-10. PMID:10339566
- ↑ Friedman DB, Kern JW, Huneycutt BJ, Vinh DB, Crawford DK, Steiner E, Scheiltz D, Yates J 3rd, Resing KA, Ahn NG, Winey M, Davis TN. Yeast Mps1p phosphorylates the spindle pole component Spc110p in the N-terminal domain. J Biol Chem. 2001 May 25;276(21):17958-67. Epub 2001 Mar 6. PMID:11278681 doi:http://dx.doi.org/10.1074/jbc.M010461200
- ↑ Mirzayan C, Copeland CS, Snyder M. The NUF1 gene encodes an essential coiled-coil related protein that is a potential component of the yeast nucleoskeleton. J Cell Biol. 1992 Mar;116(6):1319-32. PMID:1541631
- ↑ Huisman SM, Smeets MF, Segal M. Phosphorylation of Spc110p by Cdc28p-Clb5p kinase contributes to correct spindle morphogenesis in S. cerevisiae. J Cell Sci. 2007 Feb 1;120(Pt 3):435-46. Epub 2007 Jan 9. PMID:17213332 doi:http://dx.doi.org/10.1242/jcs.03342
- ↑ Kilmartin JV, Dyos SL, Kershaw D, Finch JT. A spacer protein in the Saccharomyces cerevisiae spindle poly body whose transcript is cell cycle-regulated. J Cell Biol. 1993 Dec;123(5):1175-84. PMID:7503995
- ↑ Knop M, Schiebel E. Spc98p and Spc97p of the yeast gamma-tubulin complex mediate binding to the spindle pole body via their interaction with Spc110p. EMBO J. 1997 Dec 1;16(23):6985-95. PMID:9384578 doi:http://dx.doi.org/10.1093/emboj/16.23.6985
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