| Structural highlights
3zxr is a 6 chain structure with sequence from Myctu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | , , , , |
| Related: | 1hto, 1htq, 2whi, 2bvc, 2wgs, 3zxv |
| Activity: | Glutamate--ammonia ligase, with EC number 6.3.1.2 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Publication Abstract from PubMed
Mycobacterium tuberculosis glutamine synthetase (MtGS) is a promising target for antituberculosis drug discovery. In a recent high-throughput screening study we identified several classes of MtGS inhibitors targeting the ATP-binding site. We now explore one of these classes, the 2-tert-butyl-4,5-diarylimidazoles, and present the design, synthesis, and X-ray crystallographic studies leading to the identification of MtGS inhibitors with submicromolar IC(50) values and promising antituberculosis MIC values.
Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors.,Gising J, Nilsson MT, Odell LR, Yahiaoui S, Lindh M, Iyer H, Sinha AM, Srinivasa BR, Larhed M, Mowbray SL, Karlen A J Med Chem. 2012 Mar 22;55(6):2894-8. Epub 2012 Mar 8. PMID:22369127[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Gising J, Nilsson MT, Odell LR, Yahiaoui S, Lindh M, Iyer H, Sinha AM, Srinivasa BR, Larhed M, Mowbray SL, Karlen A. Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors. J Med Chem. 2012 Mar 22;55(6):2894-8. Epub 2012 Mar 8. PMID:22369127 doi:10.1021/jm201212h
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