Structural highlights
4f4b is a 2 chain structure with sequence from Baker's yeast. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | |
| Related: | 1zhy, 1zhx |
| Gene: | KES1, OSH4, YPL145C, LPI3C, P2614 (Baker's yeast) |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[KES1_YEAST] Plays a role in ergosterol synthesis.
Publication Abstract from PubMed
We have synthesized 16,22-diketocholesterol, a novel ligand for oxysterol-binding protein Osh4, and determined X-ray structure of the diketocholesterol in complex with Osh4. The X-ray structure shows that alpha7 helix of Osh4 assumes open conformation while the rest of Osh4, closed conformation, implying this diketocholesterol-bound Osh4 structure may represent a structural intermediate between the two conformations.
Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4.,Koag MC, Cheun Y, Kou Y, Ouzon-Shubeita H, Min K, Monzingo AF, Lee S Steroids. 2013 Jun 10;78(9):938-944. doi: 10.1016/j.steroids.2013.05.016. PMID:23756172[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Koag MC, Cheun Y, Kou Y, Ouzon-Shubeita H, Min K, Monzingo AF, Lee S. Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4. Steroids. 2013 Jun 10;78(9):938-944. doi: 10.1016/j.steroids.2013.05.016. PMID:23756172 doi:10.1016/j.steroids.2013.05.016
