Structural highlights
Publication Abstract from PubMed
The radical SAM enzyme, spore photoproduct lyase, requires an H-atom transfer (HAT) pathway to catalyze DNA repair. By rational engineering, we demonstrate that it is possible to rewire its HAT pathway, a first step toward the development of novel catalysts based on the radical SAM enzyme scaffold.
Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase.,Benjdia A, Heil K, Winkler A, Carell T, Schlichting I Chem Commun (Camb). 2014 Oct 6. PMID:25285338[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Benjdia A, Heil K, Winkler A, Carell T, Schlichting I. Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase. Chem Commun (Camb). 2014 Oct 6. PMID:25285338 doi:http://dx.doi.org/10.1039/c4cc05158k
