Ribosomal protein S24

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Contents 1 Function 2 Disease 3 3D Structures of Ribosomal protein S24 3.1 S24 4 References

Function

Ribosomal protein S24 (RPS24 in eukaryotes/archaea) is one of the ca. 33 proteins which belong to the small 40S subunit of the ribosome. It is found also in the small 30S subunit in archaea^[1].

Disease

RPS24 mutations are found in patients with Diamond-Blackfan disease^[2].

3D Structures of Ribosomal protein S24

Updated on 17-August-2016

S24

2v94 – RPS24 – Pyroccocus abyssi
2g1d – RPS24 – NMR – Thermoplasma acidophilum
1ywx - RPS24 – NMR – Methanoccocus maripaludis
1xn9 - RPS24 – NMR – Methanosarcina mazei

References

1. ↑ Xu L, He GP, Li A, Ro HS. Molecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAs. Nucleic Acids Res. 1994 Feb 25;22(4):646-55. PMID:8127713
2. ↑ Gazda HT, Grabowska A, Merida-Long LB, Latawiec E, Schneider HE, Lipton JM, Vlachos A, Atsidaftos E, Ball SE, Orfali KA, Niewiadomska E, Da Costa L, Tchernia G, Niemeyer C, Meerpohl JJ, Stahl J, Schratt G, Glader B, Backer K, Wong C, Nathan DG, Beggs AH, Sieff CA. Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia. Am J Hum Genet. 2006 Dec;79(6):1110-8. Epub 2006 Nov 2. PMID:17186470 doi:10.1086/510020