User:John Karanicolas
From Proteopedia
Dr. John Karanicolas is currently an associate professor at the Fox Chase Cancer Center.
His primary goal is to develop structure-based approaches for modulating protein function using small-molecules. His lab explores two parallel paths towards this overarching goal: the first is re-engineering proteins so that a small-molecule can be used to “turn on” function, and the second is identifying small-molecules that naturally complement and occlude a protein surface to “turn off” function. They apply these tools to understand how specific protein interactions are responsible for normal and aberrant signal transduction in cells.
