Single-stranded DNA-binding protein

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Single-stranded DNA-binding protein (SSB) binds to single-stranded regions of DNA (ssDNA) to protect it from annealing, prevention of secondary structure formation and digestion. SSB binds to DNA in a sequence-independent manner. The binding of SSB enables processes like replication, DNA repair and recombination to occur. SSB can form complexes with specific genome maintenance proteins helping their activities.

  • Viral SSB proteins are monomeric.
  • Eukaryotic SSB (Replication protein A – RPA) is a heterotrimer composed of RPA70, RPA32 and RPA14. RPA has 6 DNA-binding domains (DBD).
  • Mitochondrial human SSB (HsmtSSB) is a homotetramer.

See also Single stranded binding protein.

3D Structures of single-stranded DNA-binding protein

Updated on 30-August-2016

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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