Sphingomyelinase

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Template:STRUCTURE 1zwx

Contents 1 Function 2 Disease 3 3D structures of sphingomyelinase 4 References

Function

Sphingomyelinase (SMase) is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and ceramide^[1]. The SMase is classified into 5 types according to their pH dependence and cation dependence.

Disease

Mutations in acid SMase are found in patients with Niemann-Pick disease^[2].

3D structures of sphingomyelinase

Updated on 31-August-2016

3rlh, 3rlg – SMase D (mutant) – Loxosceles intermedia
1xx1, 2f9r – SMase I – Loxosceles laeta
1zwx – SMase C – Listeria ivanovii
2ddr, 2dds, 2ddt – BcSMase + cation – Bacillus cereus
2uyr – BcSMase (mutant)
3wcx – SMase C – Streptomyces griseocarneus

References

1. ↑ Chatterjee S. Neutral sphingomyelinase: past, present and future. Chem Phys Lipids. 1999 Nov;102(1-2):79-96. PMID:11001563
2. ↑ Wasserstein MP, Aron A, Brodie SE, Simonaro C, Desnick RJ, McGovern MM. Acid sphingomyelinase deficiency: prevalence and characterization of an intermediate phenotype of Niemann-Pick disease. J Pediatr. 2006 Oct;149(4):554-9. PMID:17011332 doi:http://dx.doi.org/10.1016/j.jpeds.2006.06.034